神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90007902
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2024-03-28
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90007902 (fulltext)
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メタデータID
90007902
アクセス権
open access
出版タイプ
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タイトル
Development and validation of an analysis method for pesticide residues by gas chromatography-tandem mass spectrometry in Daikenchuto
著者
Saegusa, Hirokazu ; Nomura, Hiroshi ; Takao, Masaki ; Hamaguchi, Takashi ; Yoshida, Masaru ; Kodama, Yuzo
著者名
Saegusa, Hirokazu
著者名
Nomura, Hiroshi
著者名
Takao, Masaki
著者名
Hamaguchi, Takashi
著者ID
A0791
研究者ID
1000000419475
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.b42c4a25405e79a1520e17560c007669.html
著者名
Yoshida, Masaru
吉田, 優
ヨシダ, マサル
所属機関名
医学研究科
著者ID
A2301
研究者ID
1000080378687
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.464addb6eeafabbc520e17560c007669.html
著者名
Kodama, Yuzo
児玉, 裕三
コダマ, ユウゾウ
所属機関名
医学研究科
収録物名
Journal of Natural Medicines
巻(号)
75(2)
ページ
344-360
出版者
Springer Nature
刊行日
2021-03
公開日
2021-03-08
抄録
Daikenchuto (DKT) is one of the most widely used "Kampo" in Japan as a representative of herbal medicine. Because DKT is made from a natural product like food, it requires the management of pesticides; therefore, an analysis of residual pesticides in Kampo is required. The World Health Organization (WHO) indicates that pesticide residue analysis by the U.S. Pharmacopeia (USP) is required. USP defines 107 compounds containing organochlorine pesticides and organophosphorus pesticides and their metabolites, which have a high residual risk. Accordingly, to guarantee the safety of herbal medicines according to global standards is a very important issue. In this study, we developed an analytical method for 91 compounds, which are listed in USP, using DKT as the subject. The method could extract pesticides from DKT with acetone, elute pesticides with acetonitrile using a SepPak C18 column (5 g) and with ethyl acetate using a DSC-NH2 column (2 g), and perform simultaneous analyses by gas chromatography-tandem mass spectrometry (GC-MS/MS). This method, which could quantify 88 compounds, was validated according to USP. A pesticide residue analysis method that meets USP requirements enables the analysis of pesticide residues with a high residue risk and contributes to improving the safety of "Kampo" and other herbal medicines.
キーワード
Herbal medicine
U.S pharmacopeia
Matrix effect
Organophosphorous pesticides
カテゴリ
医学研究科
学術雑誌論文
権利
© The Author(s) 2021.
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
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資源タイプ
journal article
言語
English (英語)
ISSN
1340-3443
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eISSN
1861-0293
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NCID
AA12114658
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関連情報
DOI
https://doi.org/10.1007/s11418-020-01473-y
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