神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90007943
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2024-04-25
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90007943 (fulltext)
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6.95 MB
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メタデータID
90007943
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
A novel topical treatment for bone metastases using a gelatin hydrogel incorporating cisplatin as a sustained release system
著者
Kanda, Yutaro ; Kakutani, Kenichiro ; Yurube, Takashi ; Zhang, Zhongying ; Miyazaki, Shingo ; Kakiuchi, Yuji ; Takeoka, Yoshiki ; Tsujimoto, Ryu ; Miyazaki, Kunihiko ; Kawamoto, Teruya ; Takada, Toru ; Hoshino, Yuichi ; Tabata, Yasuhiko ; Kuroda, Ryosuke
著者名
Kanda, Yutaro
著者ID
A1461
研究者ID
1000010533739
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=3401110282b6c620520e17560c007669
著者名
Kakutani, Kenichiro
角谷, 賢一朗
カクタニ, ケンイチロウ
所属機関名
医学研究科
著者ID
A2131
研究者ID
1000010514648
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=564b5b743f5a7d84520e17560c007669
著者名
Yurube, Takashi
由留部, 崇
ユルベ, タカシ
所属機関名
医学部附属病院
著者名
Zhang, Zhongying
著者名
Miyazaki, Shingo
著者名
Kakiuchi, Yuji
著者名
Takeoka, Yoshiki
著者名
Tsujimoto, Ryu
著者名
Miyazaki, Kunihiko
著者ID
A1442
研究者ID
1000030420558
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=73f74c173ee77724520e17560c007669
著者名
Kawamoto, Teruya
河本, 旭哉
カワモト, テルヤ
所属機関名
医学部附属病院
著者名
Takada, Toru
著者ID
A2110
研究者ID
1000040718384
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=0aa4f19f742eecd3520e17560c007669
著者名
Hoshino, Yuichi
星野, 祐一
ホシノ, ユウイチ
所属機関名
医学部附属病院
著者名
Tabata, Yasuhiko
著者ID
A0783
研究者ID
1000080379362
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=f51cbfc82378ae63520e17560c007669
著者名
Kuroda, Ryosuke
黒田, 良祐
クロダ, リョウスケ
所属機関名
医学研究科
収録物名
Journal of Orthopaedic Research
巻(号)
39(3)
ページ
525-535
出版者
Wiley
刊行日
2021-03
公開日
2022-04-01
抄録
Management of bone metastasis is becoming increasingly important. Thus, local and systemic treatment options have been developed for control. Although systemic administration of anticancer agents is effective for bone metastasis, it is often stopped because of poor general conditions or side effects. Therefore, it is highly desirable to develop a more effective and safer local treatment for bone metastasis. The purpose of the current study was to investigate the antitumor effects and safety of gelatin hydrogel microspheres incorporating cisplatin (GM-CDDP), which we developed as a sustained release system without harmful substances. First, we assessed GM-CDDP for its in vitro degradability and potential for sustained release. Second, in vivo antitumor and side effects were evaluated using a murine bone metastasis model of MDA-MB-231 human breast cancer cells incorporating GFP. In vitro, initial bursts were observed within 2 h and CDDP was released gradually with gelatin hydrogel degradation, which reached 100% at 48 h. In vivo, local administration of GM-CDDP (2 mg/kg) significantly suppressed tumor growth and bone osteolysis compared with the control, and local and systemic administration of free CDDP (2 mg/kg; p < 0.05). Local administration of GM-CDDP significantly reduced loss of body weight and elevation of blood urea nitrogen compared with the systemic administration of free CDDP (p < .05). The current study suggests that local administration of GM-CDDP achieves higher antitumor effects with a potential for lesser side effects compared with local or systemic administration of free CDDP.
キーワード
antitumor drug
bone metastasis
CDDP
gelatin hydrogel
sustained release
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2020 Orthopaedic Research Society. Published by Wiley Periodicals LLC. This is the peer reviewed version of the following article: [Kanda, Y, Kakutani, K, Yurube, T, et al. A novel topical treatment for bone metastases using a gelatin hydrogel incorporating cisplatin as a sustained release system. J Orthop Res. 2021; 39: 525-535.], which has been published in final form at https://doi.org/10.1002/jor.24874. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
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資源タイプ
journal article
言語
English (英語)
ISSN
0736-0266
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eISSN
1554-527X
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NCID
AA10625350
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関連情報
DOI
https://doi.org/10.1002/jor.24874
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