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https://hdl.handle.net/20.500.14094/90008384
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2024-05-02
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90008384 (fulltext)
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メタデータID
90008384
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Effects of fasting and re-feeding on the expression of CCK, PYY, hypothalamic neuropeptides, and IGF-related genes in layer and broiler chicks
著者
Kewan, Ahmed ; Saneyasu, Takaoki ; Kamisoyama, Hiroshi ; Honda, Kazuhisa
著者名
Kewan, Ahmed
著者ID
A1070
研究者ID
1000020721236
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=df36e67b8c5e6d0f520e17560c007669
著者名
Saneyasu, Takaoki
實安, 隆興
サネヤス, タカオキ
所属機関名
農学研究科
著者ID
A1688
研究者ID
1000090263889
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=a5d0c0332482fec4520e17560c007669
著者名
Kamisoyama, Hiroshi
上曽山, 博
カミソヤマ, ヒロシ
所属機関名
農学研究科
著者ID
A1044
研究者ID
1000040335427
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=ff13ab9e186eb62c520e17560c007669
著者名
Honda, Kazuhisa
本田, 和久
ホンダ, カズヒサ
所属機関名
農学研究科
収録物名
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology
巻(号)
257
ページ
110940
出版者
Elsevier
刊行日
2021-07
公開日
2022-08-01
抄録
Cholecystokinin (CCK) and peptide YY (PYY) have been investigated as gut hormones that send satiation signals to the brain in mammals. There is evidence that chicken PYY mRNA expression was the highest in the pancreas compared to other tissues. We recently suggested that insulin-like growth factor (IGF)-1 and its binding proteins (IGFBPs) may be involved in the appetite regulation system in chicks. In the present study, in order to evaluate the possible roles of CCK, PYY, and IGF-related proteins in the appetite regulation system in chicks, we analyzed changes in the mRNA levels of these genes in response to fasting and re-feeding in layer and hyperphagic broiler chicks. In layer chicks, 12 h of fasting reduced the mRNA levels of intestinal CCK, PYY, Y2 receptor, and pancreatic PYY, and these changes were reversed by 12 h of re-feeding. On the other hand, in broiler chicks 12 h of fasting reduced the mRNA levels of intestinal PYY and Y2 receptor, but not intestinal CCK and pancreatic PYY, and these changes were reversed by 12 h of re-feeding. Hypothalamic NPY mRNA significantly increased by 12 h of fasting in both chicks, and these changes were reversed by re-feeding. Also, 12 h of fasting significantly increased the mRNA levels of hypothalamic agouti-related protein and reduced the mRNA levels of hepatic IGF-1 only in broiler chicks, and 12 h of re-feeding did not change these. IGFBP-1 and -2 mRNA levels were markedly increased by 12 h of fasting in both chicks, and these changes were reversed by re-feeding. IGFBP-3 mRNA levels were increased by 12 h of fasting only in layer chicks, while re-feeding reduced the mRNA levels of IGFBP-3 in both types of chicks. These results suggest that several peripheral hormones, such as pancreatic PYY and intestinal CCK, may not play important roles in the regulation of food intake in broiler chicks.
キーワード
Anorexigenic peptides
Avian
Chicks
Feed intake
Gut
カテゴリ
農学研究科
学術雑誌論文
権利
© 2021 Elsevier Inc.
This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
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資源タイプ
journal article
言語
English (英語)
ISSN
1095-6433
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NCID
AA11183804
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関連情報
DOI
https://doi.org/10.1016/j.cbpa.2021.110940
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