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https://doi.org/10.24546/00098337
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2024-04-26
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00098337 (fulltext)
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00098337
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open access
出版タイプ
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タイトル
A Multi-institutional Study on Adjuvant Chemotherapy for the Prevention of Post-operative Liver Metastases in Colorectal Cancer Patients : Comparison Between Hepatic Arterial and Portal Adriamycin Plus Oral UFT Administration
著者
Nakamura, Takeshi ; Tabuchi, Yoshiki ; Ohno, Masakazu ; Kamigaki, Takashi ; Kuroda, Yoshikazu
著者名
Nakamura, Takeshi
著者名
Tabuchi, Yoshiki
著者名
Ohno, Masakazu
著者名
Kamigaki, Takashi
著者名
Kuroda, Yoshikazu
収録物名
Bulletin of health sciences Kobe
巻(号)
17
ページ
81-88
出版者
Graduate School of Health Sciences, Kobe University
刊行日
2001-11-30
公開日
2006-09-11
注記
本文ファイルは、国立情報学研究所CiNiiより提供されたものです。
抄録
In order to clarify which is more effective for the prevention of post-operative liver metastases in colorectal cancer patients, adjuvant chemotherapy consisting of hepatic arterial or intra-portal adriamycin (ADM) plus oral UFT administration was examined as an open trial of multi-institutions. Patients were given ADM 20 mg/m^2 via the hepatic artery in intra-arterial group (IA group) and the portal vein in intra-portal. Group (IP group) just after the resection of cancer lesions, respectively. Thereafter, all of the patients were orally treated with UFT 270 mg/ m^2/day for 2 years. Forty-five colorectal cancer patients with curability A and B, 12 patients in the IA group and 33 in the IP group, were enrolled in the study. No statistical difference was found in 12 clinicopathological variables between the groups. Five-year survival rate was 80.8% in the IA group and 89.9% in the IP group. Although various types of post-operative metastases were found in 25.0% in the former and 21.2% in the latter, the liver metastasis was not found in the IA group. The metastasis was found in 5 patients of the IP group. There was no statistical difference in the survival and liver metastatic curves or rates between the groups. These results suggest that the intra-arterial adjuvant chemotherapy for colorectal cancer patients is not beneficial to the prophylaxis of post-operative liver metastases, in comparison with the intra-portal chemotherapy.
キーワード
Hepatic arterial infusion
Intra-portal infusion
Adriamycin (ADM)
Liver metastasis
Colorectal cancer
カテゴリ
Bulletin of health sciences Kobe
>
17号(2001-11-30)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
1346-8707
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AA11316362
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関連情報
NAID
110004599724
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