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https://doi.org/10.24546/81000885
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2024-04-26
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81000885 (fulltext)
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メタデータID
81000885
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open access
出版タイプ
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タイトル
Hepatitis B virus-positive blood donors in the early stages of Hepatitis B virus infection : Significance of nucleic acid amplification testing
著者
Yamashita, Mariko ; Mito, Hisashi ; Imoto, Shion ; Nishiyama, Kaoru
著者名
Yamashita, Mariko
著者名
Mito, Hisashi
著者名
Imoto, Shion
著者名
Nishiyama, Kaoru
収録物名
Bulletin of health sciences Kobe
巻(号)
23
ページ
9-19
出版者
Graduate School of Health Sciences, Kobe University
刊行日
2007
公開日
2009-03-13
注記
本文ファイルは、国立情報学研究所CiNiiより提供されたものです。
抄録
Since 1999, 1,387,094 units of serologically negative blood donations to the Hyogo Blood Center have been screened by nucleic acid amplification testing (NAT). Thirty hepatitis B virus (HBV)-DNA positive donors were identified from among all the donors. Twenty-one out of the 30 selected donors were contacted and monitored with their courtesy and consent. Their HBV serological markers, HBV copy number, and alanine transaminase (ALT) levels were analyzed. They were then classified into three groups according to the pattern of increase in their ALT levels. Nine cases in Group I showed more than 1,000 IU/L ALT and 9 cases in Group II showed slightly higher levels. Because the monitoring started during the very early stage of the serological negative period, all the phenomena associated with the development of typical hepatitis symptoms became evident in Groups I and II. On the other hand, the ALT levels of three cases in Group III remained within the normal range or only slightly increased, and these three were asymptomatic for hepatitis B. In two cases, a single nucleotide substitution, G1896A, was observed in the precore region but not in the core promoter region; this substitution result in the tryptophan codon (TGG) being converted to a stop codon (TAG). Another case showed a mixed type mutation involving the wild type and G1896A substitution. Although many reports on fulminant or subfulminant hepatitis patients associated with precore-defective HBV mutants have been published, asymptomatic hepatitis B patient with precore-defective HBV mutants have not been reported. Thus, it is suggested that a mutation in the core promoter (T1754C/G and/or A1762T/G1764A) might cause an increase in the viral growth rate or suppression for viral increase.
キーワード
Nucleic acid amplification testing
NAT
Asymptomatic B hepatitis
Hepatitis B virus
Precore-defective HBV mutants
カテゴリ
Bulletin of health sciences Kobe
>
23号(2007)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
1346-8707
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NCID
AA11316362
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関連情報
NAID
110006979184
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