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https://doi.org/10.24546/81005510
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2024-03-29
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81005510 (fulltext)
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メタデータID
81005510
アクセス権
open access
出版タイプ
Version of Record
タイトル
Cognitive Impairments in Patients with Diffuse Axonal Injury
著者
Ubukata, Shiho ; Tanemura, Rumi ; Murai, Toshiya ; Ueda, Keita
著者名
Ubukata, Shiho
著者名
Tanemura, Rumi
著者名
Murai, Toshiya
著者名
Ueda, Keita
収録物名
Bulletin of health sciences Kobe
巻(号)
29
ページ
17-25
出版者
Graduate School of Health Sciences, Kobe University
刊行日
2013
公開日
2014-04-04
抄録
Focal brain injury and diffuse axonal injury (DAI) are two major types of traumatic brain injury. It is well established that patients with frontal lobe injury show cognitive impairments. However, the neurocognitive sequelae of DAI and the neural basis of the associated symptoms are poorly understood. To examine these parameters, in this study, 10 patients with DAI (10 males, 30.8 ± 10.5 years) and 12 age and gender matched normal control subjects underwent neuropsychological assessments and high-resolution structural magnetic resonance imaging (MRI). Voxel-based morphometry (VBM) was applied to investigate regional brain alterations. In patients with DAI, the mean WAIS-III IQ was 79.9±10.9, while the Eyes test score was worse than that in normal subjects. In VBM analyses, DAI patients exhibited widespread subcortical grey matter (GM) reductions, including the thalamus, cingulate cortex, insula, and putamen. Further, the IQ index of processing speed in DAI patients was associated with GM reduction in the right thalamus, while of the Eyes test scores were associated with GM reduction in the left amygdala. This preliminary study suggests that a specific brain network may play a key role in the development of cognitive impairments in DAI.
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Bulletin of health sciences Kobe
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29号(2013)
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資源タイプ
departmental bulletin paper
言語
English (英語)
ISSN
1346-8707
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AA11316362
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