| 本文URL |  ダウンロード回数： 回 |
| ID | 90004464 |
| 資源タイプ | |
| 版区分 | publisher |
| タイトル | Mechanism of M-cell differentiation accelerated by proliferation of indigenous bacteria in rat Peyer's patches |
| 著者ID | / A1072 / / / / A0061 / A1228 / A1017 / A0039 / A0037 |
| 著者 | Yuasa, Hideto Mantani, Youhei   Masuda, Natsumi Nishida, Miho Arai, Masaya Yokoyama, Toshifumi Tsuruta, Hiroki Kawano, Junichi Hoshi, Nobuhiko Kitagawa, Hiroshi |
| 著者別表記 | / 万谷, 洋平 / / / / 横山, 俊史 / 鶴田, 宏樹 / 河野, 潤一 / 星, 信彦 / 北川, 浩 |
| 著者ヨミ | |
| 著者所属 | |
| 掲載誌 | |
| 巻号 | 79(11) |
| ページ | 1826-1835 |
| 公開者 | Japanese Society of Veterinary Science |
| 刊行日 | 2017-11 |
| 権利 | ©2017 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
| 公開日 | 2018-01-10 |
| ISSN | 09167250  |
| eISSN | 13477439 |
| DOI | 10.1292/jvms.17-0470 |
| 言語 | eng |
| 研究者ID | / 1000030724984 / / / / 1000010380156 / 1000020346282 / 1000040127361 / 1000010209223 / 1000040125307 |
| 内容記述 | The mechanism by which indigenous bacteria on the follicle-associated epithelium (FAE) of lymphatic follicles (LFs) accelerate the differentiation of microvillous columnar epithelial cells (MV) into M-cells was immunohistochemically investigated in rat Peyer's patches. The results showed that the number of Toll-like receptor (TLR) -4(+) M-cells was greater in the FAE with expansion of bacterial colonies (LFs with bacterial colonies on the FAE: b-LF) than the FAE without expansion of bacterial colonies (nb-LF). TLR-4 was also expressed in the striated borders of MV upstream next to M-cells in the FAE of the b-LF. TLR-4(+) vesicles were frequently detected in the cytoplasms of MV with TLR-4(+) striated borders upstream next to TLR-4(+) M-cells in the FAE of b-LF. These findings suggest that TLR-4(+) MV take up TLR-4 ligands and differentiate into M-cells in the b-LF. Neither the distribution of RANK nor that of RANKL was coincident with that of M-cells in the b-LF. Moreover, RANK, but not RANKL, was expressed in intestinal villi, whereas cleaved caspase-3 was immunonegative in the MV and M-cells of the FAE, unlike in villous epithelial cells. Therefore, RANK/RANKL signaling in the LF might contribute to the down-regulation of epithelial apoptosis to facilitate the differentiation of MV into M-cells in rat Peyer's patches. |
| キーワード | immunohistochemistry / indigenous bacteria / M-cell differentiation / Peyer's patch / rat |
| KUID | / https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.baf1f569c1518783520e17560c007669.html / / / / https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.158c55140a1540e9520e17560c007669.html / https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.de8664305b265e9c520e17560c007669.html / / https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.fa741cc09ab44f05520e17560c007669.html / |
| データ登録日 | 2018-01-10 |
