| 本文URL |  ダウンロード回数： 回 |
| ID | 90006605 |
| 資源タイプ | |
| 版区分 | publisher |
| タイトル | Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity |
| 著者ID | / A0029 / / A1943 / / A2318 / A2535 / / / / / / / / / / / |
| 著者 | Kato, Daisuke Wake, Hiroaki   Lee, Philip R. Tachibana, Yoshihisa Ono, Riho Sugio, Shouta Tsuji, Yukio Tanaka, Yasuyo H. Tanaka, Yasuhiro R. Masamizu, Yoshito Hira, Riichiro Moorhouse, Andrew J. Tamamaki, Nobuaki Ikenaka, Kazuhiro Matsukawa, Noriyuki Fields, R. Douglas Nabekura, Junichi Matsuzaki, Masanori |
| 著者別表記 | / 和氣, 弘明 / / 橘, 吉寿 / / 杉尾, 翔太 / 辻, 佑木生 / / / / / / / / / / / |
| 著者ヨミ | |
| 著者所属 | |
| 掲載誌 | |
| 巻号 | 68(1) |
| ページ | 193-210 |
| 公開者 | Wiley |
| 刊行日 | 2020-01 |
| 権利 | © 2019 The Authors. Glia published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
| 公開日 | 2019-12-13 |
| ISSN | 08941491  |
| eISSN | 10981136 |
| NCID | AA11620396 |
| DOI | 10.1002/glia.23713 |
| 資源情報1 | |
| 言語 | eng |
| 研究者ID | / 1000090455220 / / 1000050373197 / / 1000030825344 / 1000080850560 / / / / / / / / / / / |
| 内容記述 | Myelination increases the conduction velocity in long-range axons and is prerequisite for many brain functions. Impaired myelin regulation or impairment of myelin itself is frequently associated with deficits in learning and cognition in neurological and psychiatric disorders. However, it has not been revealed what perturbation of neural activity induced by myelin impairment causes learning deficits. Here, we measured neural activity in the motor cortex during motor learning in transgenic mice with a subtle impairment of their myelin. This deficit in myelin impaired motor learning, and was accompanied by a decrease in the amplitude of movement-related activity and an increase in the frequency of spontaneous activity. Thalamocortical axons showed variability in axonal conduction with a large spread in the timing of postsynaptic cortical responses. Repetitive pairing of forelimb movements with optogenetic stimulation of thalamocortical axon terminals restored motor learning. Thus, myelin regulation helps to maintain the synchrony of cortical spike-time arrivals through long-range axons, facilitating the propagation of the information required for learning. Our results revealed the pathological neuronal circuit activity with impaired myelin and suggest the possibility that pairing of noninvasive brain stimulation with relevant behaviors may ameliorate cognitive and behavioral abnormalities in diseases with impaired myelination. |
| キーワード | axonal conduction / calcium imaging / motor learning / myelination / neuron–glia interactions / oligodendrocyte / optogenetics |
| KUID | / https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.0dd6999dcebbbf8b520e17560c007669.html / / https://kuid-rm-web.ofc.kobe-u.ac.jp/profile/ja.5e6e4f83c9433d28520e17560c007669.html / / / / / / / / / / / / / / |
| データ登録日 | 2019-12-13 |
