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90007385

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A possible beneficial effect of Bacteroides on faecal lipopolysaccharide activity and cardiovascular diseases

/ A1385 / / / A0278 / A0276 / / / / / / / / / A1682 / A1715 / / / A0883

Yoshida, Naofumi
Yamashita, Tomoya
Kishino, Shigenobu
Watanabe, Hikaru
Sasaki, Kengo
Sasaki, Daisuke
Tabata, Tokiko
Sugiyama, Yuta
Kitamura, Nahoko
Saito, Yoshihiro
Emoto, Takuo
Hayashi, Tomohiro
Takahashi, Tomoya
Shinohara, Masakazu
Osawa, Ro
Kondo, Akihiko
Yamada, Takuji
Ogawa, Jun
Hirata, Ken-ichi

/ 山下, 智也 / / / 佐々木, 建吾 / 佐々木, 大介 / / / / / / / / / 大澤, 朗 / 近藤, 昭彦 / / / 平田, 健一

10(1)

13009

Nature Research

2020-08-03

© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

2020-08-25

20452322

eng

/ 1000090437468 / / / 1000050558301 / 1000000650615 / / / / / / / / / 1000010253189 / 1000040205547 / / / 1000020283880

Faecal lipopolysaccharides (LPS) have attracted attention as potent elements to explain a correlation between the gut microbiota and cardiovascular disease (CVD) progression. However, the underlying mechanism of how specific gut bacteria contribute to faecal LPS levels remains unclear. We retrospectively analysed the data of 92 patients and found that the abundance of the genus Bacteroides was significantly and negatively correlated with faecal LPS levels. The controls showed a higher abundance of Bacteroides than that in the patients with CVD. The endotoxin units of the Bacteroides LPS, as determined by the limulus amoebocyte lysate (LAL) tests, were drastically lower than those of the Escherichia coli LPS; similarly, the Bacteroides LPS induced relatively low levels of pro-inflammatory cytokine production and did not induce sepsis in mice. Fermenting patient faecal samples in a single-batch fermentation system with Bacteroides probiotics led to a significant increase in the Bacteroides abundance, suggesting that the human gut microbiota could be manipulated toward decreasing the faecal LPS levels. In the clinical perspective, Bacteroides decrease faecal LPS levels because of their reduced LAL activity; therefore, increasing Bacteroides abundance might serve as a novel therapeutic approach to prevent CVD via reducing faecal LPS levels and suppressing immune responses.

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2020-08-25