神戸大学附属図書館デジタルアーカイブ
入力補助
English
カテゴリ
学内刊行物
ランキング
アクセスランキング
ダウンロードランキング
https://hdl.handle.net/20.500.14094/90004400
このアイテムのアクセス数:
17
件
(
2024-05-06
10:53 集計
)
閲覧可能ファイル
ファイル
フォーマット
サイズ
閲覧回数
説明
90004400 (fulltext)
pdf
1.78 MB
9
メタデータ
ファイル出力
メタデータID
90004400
アクセス権
open access
出版タイプ
Version of Record
タイトル
Investigations in the possibility of early detection of colorectal cancer by gas chromatography/triple-quadrupole mass spectrometry
著者
Nishiumi, Shin ; Kobayashi, Takashi ; Kawana, Shuichi ; Unno, Yumi ; Sakai, Takero ; Okamoto, Koji ; Yamada, Yasuhide ; Sudo, Kazuki ; Yamaji, Taiki ; Saito, Yutaka ; Kanemitsu, Yukihide ; Okita, Natsuko Tsuda ; Saito, Hiroshi ; Tsugane, Shoichiro ; Azuma, Takeshi ; Ojima, Noriyuki ; Yoshida, Masaru
著者ID
A0815
研究者ID
1000020514706
著者名
Nishiumi, Shin
西海, 信
ニシウミ, シン
所属機関名
医学研究科
著者ID
A0869
研究者ID
1000090709669
著者名
Kobayashi, Takashi
小林, 隆
コバヤシ, タカシ
所属機関名
医学研究科
著者名
Kawana, Shuichi
著者名
Unno, Yumi
著者名
Sakai, Takero
著者名
Okamoto, Koji
著者名
Yamada, Yasuhide
著者名
Sudo, Kazuki
著者名
Yamaji, Taiki
著者名
Saito, Yutaka
著者名
Kanemitsu, Yukihide
著者名
Okita, Natsuko Tsuda
著者名
Saito, Hiroshi
著者名
Tsugane, Shoichiro
著者ID
A0058
研究者ID
1000060221040
著者名
Azuma, Takeshi
東, 健
アズマ, タケシ
所属機関名
医学研究科
著者名
Ojima, Noriyuki
著者ID
A0791
研究者ID
1000000419475
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=b42c4a25405e79a1520e17560c007669
著者名
Yoshida, Masaru
吉田, 優
ヨシダ, マサル
所属機関名
医学研究科
収録物名
Oncotarget
巻(号)
8(10)
ページ
17115-17126
出版者
Impact Journals
刊行日
2017-03-07
公開日
2017-12-21
抄録
In developed countries, the number of patients with colorectal cancer has been increasing, and colorectal cancer is one of the most common causes of cancer death. To improve the quality of life of colorectal cancer patients, it is necessary to establish novel screening methods that would allow early detection of colorectal cancer. We performed metabolome analysis of a plasma sample set from 282 stage 0/I/II colorectal cancer patients and 291 healthy volunteers using gas chromatography/triple-quadrupole mass spectrometry in an attempt to identify metabolite biomarkers of stage 0/I/II colorectal cancer. The colorectal cancer patients included patients with stage 0 (N= 79), I (N= 80), and II (N= 123) in whom invasion and metastasis were absent. Our analytical system detected 64 metabolites in the plasma samples, and the levels of 29 metabolites differed significantly (Bonferroni-corrected p=0.000781) between the patients and healthy volunteers. Based on these results, a multiple logistic regression analysis of various metabolite biomarkers was carried out, and a stage 0/I/II colorectal cancer prediction model was established. The area under the curve, sensitivity, and specificity values of this model for detecting stage 0/I/II colorectal cancer were 0.996, 99.3%, and 93.8%, respectively. The model's sensitivity and specificity values for each disease stage were >90%, and surprisingly, its sensitivity for stage 0, specificity for stage 0, and sensitivity for stage II disease were all 100%. Our predictive model can aid early detection of colorectal cancer and has potential as a novel screening test for cases of colorectal cancer that do not involve lymph node or distant metastasis.
キーワード
metabolomics
colorectal cancer
biomarker
gas chromatography/triple-quadrupole mass spectrometry
metabolite
カテゴリ
医学研究科
学術雑誌論文
権利
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
詳細を表示
資源タイプ
journal article
言語
English (英語)
eISSN
1949-2553
OPACで所蔵を検索
CiNiiで学外所蔵を検索
関連情報
DOI
https://doi.org/10.18632/oncotarget.15081
ホームへ戻る