神戸大学附属図書館デジタルアーカイブ
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https://hdl.handle.net/20.500.14094/90006214
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2024-05-08
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90006214 (fulltext)
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メタデータID
90006214
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Ultrastructural and Immunohistochemical Study on the Lamina Propria Cells Beneath Paneth Cells in the Rat Ileum
著者
Mantani, Youhei ; Nishida, Miho ; Yamamoto, Kyouji ; Miyamoto, Kazuki ; Yuasa, Hideto ; Masuda, Natsumi ; Omotehara, Takuya ; Tsuruta, Hiroki ; Yokoyama, Toshifumi ; Hoshi, Nobuhiko ; Kitagawa, Hiroshi
著者ID
A1072
研究者ID
1000030724984
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=baf1f569c1518783520e17560c007669
著者名
Mantani, Youhei
万谷, 洋平
マンタニ, ヨウヘイ
所属機関名
農学研究科
著者名
Nishida, Miho
著者名
Yamamoto, Kyouji
著者名
Miyamoto, Kazuki
著者名
Yuasa, Hideto
著者名
Masuda, Natsumi
著者名
Omotehara, Takuya
著者ID
A1228
研究者ID
1000020346282
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=de8664305b265e9c520e17560c007669
著者名
Tsuruta, Hiroki
鶴田, 宏樹
ツルタ, ヒロキ
所属機関名
学術研究推進機構
著者ID
A0061
研究者ID
1000010380156
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=158c55140a1540e9520e17560c007669
著者名
Yokoyama, Toshifumi
横山, 俊史
ヨコヤマ, トシフミ
所属機関名
農学研究科
著者ID
A0039
研究者ID
1000010209223
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=fa741cc09ab44f05520e17560c007669
著者名
Hoshi, Nobuhiko
星, 信彦
ホシ, ノブヒコ
所属機関名
先端融合研究環
著者ID
A0037
研究者ID
1000040125307
著者名
Kitagawa, Hiroshi
北川, 浩
キタガワ, ヒロシ
所属機関名
農学研究科
収録物名
Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
巻(号)
301(6)
ページ
1074-1085
出版者
Wiley
刊行日
2018-01
公開日
2019-07-24
注記
This is the peer reviewed version of the following article: Mantani Y, Nishida M, Yamamoto K, Miyamoto K, Yuasa H, Masuda N, et al. Ultrastructural and immunohistochemical study on the lamina propria cells beneath paneth cells in the rat ileum. Anat Rec (Hoboken). (2018) 301:1074–85., which has been published in final form at https://doi.org/10.1002/ar.23778. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
抄録
Paneth cells secrete bactericidal substances in response to bacterial proliferation on the mucosal surface without directly contacting bacteria. However, the induction mechanism of this transient secretion has not been clarified, although nervous system and/or immunocompetent cells in the lamina propria (LP) might be involved. In this study, we ultrastructurally and immunohistochemically investigated which LP cells are localized beneath Paneth cells and examined the relationship between the Paneth cell‐derived cellular processes which extended into the LP and the LP cells. The results showed that various cells—including blood capillary, subepithelial stromal cell, and nerve fiber—were present in the LP beneath Paneth cells. Endothelial cells of blood capillary were the cells most frequently found in this location; they were situated within 1 μm of the Paneth cells and possessed fenestration on the surfaces adjacent to Paneth cells. The Paneth cells rarely extended the cellular processes toward the LP across the basal lamina. Most of the cellular processes of Paneth cells contacted the subepithelial stromal cells. Immunohistochemistry revealed that the CD34+CD31−αSMA− stromal cells preferentially localized in the LP beneath the intestinal crypt base, while PDGFRαhiαSMA+ stromal cells mainly localized around the lateral portions of the intestinal crypt and PDGFRαhiαSMA− stromal cells localized in the intestinal villus. From these findings, the existence of blood capillaries beneath Paneth cells might reflect the active exocrine function of Paneth cells. Furthermore, subepithelial stromal cells, probably with a CD34+CD31−αSMA− PDGFRα−/lo phenotype, beneath the crypt base might affect Paneth cell activity by interacting with their cellular processes. Anat Rec, 301:1074–1085, 2018. © 2018 Wiley Periodicals, Inc.
キーワード
ileum
Paneth cell
rat
transmission electron microscopy
カテゴリ
学術研究推進機構
先端融合研究環
農学研究科
学術雑誌論文
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資源タイプ
journal article
言語
English (英語)
ISSN
1932-8486
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eISSN
1932-8494
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NCID
AA12187935
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関連情報
DOI
https://doi.org/10.1002/ar.23778
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