神戸大学附属図書館デジタルアーカイブ
入力補助
English
カテゴリ
学内刊行物
ランキング
アクセスランキング
ダウンロードランキング
https://hdl.handle.net/20.500.14094/90006341
このアイテムのアクセス数:
27
件
(
2024-05-04
22:22 集計
)
閲覧可能ファイル
ファイル
フォーマット
サイズ
閲覧回数
説明
90006341 (fulltext)
pdf
392 KB
4
メタデータ
ファイル出力
メタデータID
90006341
アクセス権
open access
出版タイプ
Version of Record
タイトル
Effects of ipragliflozin on glycemic control, appetite and its related hormones: A prospective, multicenter, open-label study (SOAR-KOBE Study)
著者
Miura, Hiroshi ; Sakaguchi, Kazuhiko ; Okada, Yuko ; Yamada, Tomoko ; Otowa-Suematsu, Natsu ; So, Anna ; Komada, Hisako ; Hirota, Yushi ; Ohara, Takeshi ; Kuroki, Yasuo ; Hara, Kenta ; Matsuda, Tomokazu ; Kishi, Minoru ; Takeda, Akihiko ; Yokota, Kazuki ; Tamori, Yoshikazu ; Ogawa, Wataru
著者名
Miura, Hiroshi
著者ID
A1387
研究者ID
1000020444573
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cc9462ee69a7a403520e17560c007669
著者名
Sakaguchi, Kazuhiko
坂口, 一彦
サカグチ, カズヒコ
所属機関名
医学研究科
著者ID
A1553
研究者ID
1000090782433
著者名
Okada, Yuko
岡田, 裕子
オカダ, ユウコ
所属機関名
医学部附属病院
著者名
Yamada, Tomoko
著者名
Otowa-Suematsu, Natsu
著者名
So, Anna
著者名
Komada, Hisako
著者ID
A1420
研究者ID
1000080566018
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=8d8b694f29475700520e17560c007669
著者名
Hirota, Yushi
廣田, 勇士
ヒロタ, ユウシ
所属機関名
医学部附属病院
著者名
Ohara, Takeshi
著者名
Kuroki, Yasuo
著者名
Hara, Kenta
著者名
Matsuda, Tomokazu
著者名
Kishi, Minoru
著者名
Takeda, Akihiko
著者名
Yokota, Kazuki
著者ID
A1938
研究者ID
1000090379397
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=fc3ce686271f4d14520e17560c007669
著者名
Tamori, Yoshikazu
田守, 義和
タモリ, ヨシカズ
所属機関名
医学研究科
著者ID
A1358
研究者ID
1000040294219
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=38228987a3a438c8520e17560c007669
著者名
Ogawa, Wataru
小川, 渉
オガワ, ワタル
所属機関名
医学研究科
収録物名
Journal of Diabetes Investigation
巻(号)
10(5)
ページ
1254-1261
出版者
Wiley
刊行日
2019-09
公開日
2019-09-19
抄録
Aims/Introduction Sodium-glucose cotransporter 2 (SGLT-2) inhibitors improve blood glucose control, as well as reducing bodyweight by promoting urinary glucose excretion. The weight loss is less than expected from urinary glucose loss, however, likely because of an increase in food intake. To investigate whether SGLT-2 inhibitors might increase appetite by affecting related hormones, we examined the effects of the SGLT-2 inhibitor, ipragliflozin, including those on appetite-regulating hormones, in individuals with suboptimally controlled type 2 diabetes. Materials and Methods The present prospective, multicenter, open-label study was carried out with 96 patients with a body mass index of ≥22 kg/m(2) who were treated with ipragliflozin (50 mg/day) for 16 weeks. Parameters including glycated hemoglobin level, bodyweight, circulating leptin and active ghrelin concentrations, and appetite as assessed with a visual analog scale were measured before and during treatment. Results Both glycated hemoglobin level (from 7.9 ± 0.8 to 7.1 ± 0.7%) and bodyweight (from 75.2 ± 12.6 to 72.6 ± 12.4 kg) were significantly decreased after treatment for 16 weeks. The fasting serum leptin level was significantly decreased after 2 weeks (from 19.5 ± 13.1 to 18.1 ± 12.4 ng/mL) and remained decreased up to 16 weeks, even after adjustment for bodyweight, whereas the plasma active ghrelin level showed no significant change. The visual analog scale score for hunger was significantly increased at 2 and 8 weeks. Conclusions The present results suggest that ipragliflozin improved glycemic control and reduced bodyweight, but also reduced serum leptin levels and might thereby have increased appetite.
キーワード
Appetite
Ipragliflozin
Leptin
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
詳細を表示
資源タイプ
journal article
言語
English (英語)
ISSN
2040-1116
OPACで所蔵を検索
CiNiiで学外所蔵を検索
eISSN
2040-1124
OPACで所蔵を検索
CiNiiで学外所蔵を検索
NCID
AA12488319
OPACで所蔵を検索
CiNiiで表示
関連情報
DOI
https://doi.org/10.1111/jdi.13015
ホームへ戻る