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https://hdl.handle.net/20.500.14094/90007031
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2024-05-04
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90007031 (fulltext)
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メタデータID
90007031
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open access
出版タイプ
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タイトル
Oral Administration of Fucoidan Can Exert Anti-Allergic Activity after Allergen Sensitization by Enhancement of Galectin-9 Secretion in Blood
著者
Mizuno, Masashi ; Sakaguchi, Kana ; Sakane, Iwao
著者ID
A1190
研究者ID
1000000212233
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=53bfd9d6b626d7c5520e17560c007669
著者名
Mizuno, Masashi
水野, 雅史
ミズノ, マサシ
所属機関名
農学研究科
著者名
Sakaguchi, Kana
著者名
Sakane, Iwao
収録物名
Biomolecules
巻(号)
10(2)
ページ
258-258
出版者
MDPI
刊行日
2020-02
公開日
2020-04-17
抄録
A previous study revealed that fucoidan inhibited mast cell degranulation through the upregulation of galectin-9 in blood. The purpose of this study is to elucidate its mechanism using ovalbumin (OVA) induced anaphylaxis model mice (BALB/c, Female, 5-week-old) and mast cell line (RBL-2H3 cells). Oral administration of fucoidan after sensitization with OVA/Al(OH)(3) inhibited reduction of rectal temperature induced by activation of mast cells. Fucoidan increased galectin-9 mRNA expression only in colonic epithelial cells. These results suggested that fucoidan could suppress the allergic symptoms in sensitized mice by inducing galectin-9 production from colonic epithelial cells. In addition, to check the influence of galectin 9 on the degranulation of mast cells, RBL-2H3 cell lines were treated directly with recombinant galectin-9. As expected, galectin-9 inhibited degranulation of RBL-2H3 cells pre-bound with IgE. Moreover, the residual amounts of IgE on RBL-2H3 cells were decreased by an addition of galectin-9. It was demonstrated that galectin-9 could remove IgE even if IgE was already bound to mast cells and suppress the mast cells degranulation induced by antigen. This study shows that fucoidan might become an effective therapeutic agent for patients already developed type I allergic diseases.
キーワード
Anaphylaxis
fucoidan
galectin-9
mast cell
type I hypersensitivity
カテゴリ
農学研究科
学術雑誌論文
権利
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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資源タイプ
journal article
言語
English (英語)
eISSN
2218-273X
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関連情報
DOI
https://doi.org/10.3390/biom10020258
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