神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/90007335

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メタデータID
90007335
アクセス権
open access
出版タイプ
Version of Record
タイトル
Association between mean platelet volume in the pathogenesis of type 2 diabetes mellitus and diabetic macrovascular complications in Japanese patients
著者
Inoue, Hiroyuki ; Saito, Mayumi ; Kouchi, Kumiko ; Asahara, Shun-ichiro ; Nakamura, Fumihiko ; Kido, Yoshiaki
著者名
Inoue, Hiroyuki
著者名
Saito, Mayumi
著者名
Kouchi, Kumiko
著者ID
A1964
研究者ID
1000000570342
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=9aa517d3d9280b80520e17560c007669
著者名
Asahara, Shun-ichiro
淺原, 俊一郎
アサハラ, シュンイチロウ
所属機関名
医学部附属病院
著者名
Nakamura, Fumihiko
著者ID
A0779
研究者ID
1000010335440
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cce27e71728d2870520e17560c007669
著者名
Kido, Yoshiaki
木戸, 良明
キド, ヨシアキ
所属機関名
保健学研究科
収録物名
Journal of Diabetes Investigation
巻(号)
11(4)
ページ
938-945
出版者
Wiley
刊行日
2020-07
公開日
2020-08-04
抄録
Aims/Introduction Mean platelet volume (MPV) is a widely used biological marker of platelet function and activity. Increased MPV is associated with accelerated thrombopoiesis and an elevated risk of cardiovascular disease. However, it is not known whether higher MPV is related to the pathogenesis of type 2 diabetes and diabetic macrovascular complications in Japanese patients. Therefore, we analyzed MPV and its correlation with atherosclerosis in Japanese patients with type 2 diabetes and those who had prediabetes. Materials and Methods We divided the patients into three groups: normoglycemic patients (n = 56), prediabetes patients (n = 44) and type 2 diabetes patients group, (n = 115). We measured platelet parameters and evaluated arterial stiffness in the three groups. Results Significantly higher MPV was found in the type 2 diabetes mellitus and prediabetes patients compared with normoglycemic patients. MPV was significantly correlated with fasting blood glucose and glycated hemoglobin levels. Multiple linear regression analysis showed that MPV was positively correlated with HbA1c, even after adjustment for confounding factors. In the evaluation of arterial stiffness by measuring the cardio-ankle vascular index and maximum intima-media thickness, MPV showed a positive correlation with these parameters. Conclusions These findings suggest that MPV was significantly increased in the early stage of type 2 diabetes. We showed positive correlations between MPV and HbA1c levels, and between MPV and arterial stiffness in Japanese patients with type 2 diabetes.
キーワード
Arterial stiffness
Mean platelet volume
Type 2 diabetes
カテゴリ
医学部附属病院
保健学研究科
学術雑誌論文
権利
© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
CC license
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.