神戸大学附属図書館デジタルアーカイブ
https://hdl.handle.net/20.500.14094/90008470

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メタデータID
90008470
アクセス権
open access
出版タイプ
Accepted Manuscript
タイトル
Utility of glomerular Gd-IgA1 staining for indistinguishable cases of IgA nephropathy or Alport syndrome
著者
Ishiko, Shinya ; Tanaka, Akihito ; Takeda, Asami ; Hara, Masayuki ; Hamano, Naoto ; Koizumi, Masahiro ; Ueno, Toshinori ; Hayashi, Hiroki ; Kondo, Atsushi ; Nagai, Sadayuki ; Aoto, Yuya ; Sakakibara, Nana ; Nagano, China ; Horinouchi, Tomoko ; Yamamura, Tomohiko ; Ninchoji, Takeshi ; Shima, Yuko ; Nakanishi, Koichi ; Yoshikawa, Norishige ; Iijima, Kazumoto ; Nozu, Kandai
著者名
Ishiko, Shinya
石河, 慎也
イシコ, シンヤ
著者名
Tanaka, Akihito
著者名
Takeda, Asami
著者名
Hara, Masayuki
著者名
Hamano, Naoto
著者名
Koizumi, Masahiro
著者名
Ueno, Toshinori
著者名
Hayashi, Hiroki
著者名
Kondo, Atsushi
著者名
Nagai, Sadayuki
著者名
Aoto, Yuya
著者名
Sakakibara, Nana
著者ID
A2410
研究者ID
1000060814316
著者名
Nagano, China
長野, 智那
ナガノ, チナ
所属機関名
医学研究科
著者ID
A2532
研究者ID
1000030754593
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=050f3887e6a59356520e17560c007669
著者名
Horinouchi, Tomoko
堀之内, 智子
ホリノウチ, トモコ
所属機関名
医学部附属病院
著者ID
A0868
研究者ID
1000030770242
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cead95bcb1b9c2ee520e17560c007669
著者名
Yamamura, Tomohiko
山村, 智彦
ヤマムラ, トモヒコ
所属機関名
医学研究科
著者ID
A0820
研究者ID
1000010568950
著者名
Ninchoji, Takeshi
忍頂寺, 毅史
ニンチョウジ, タケシ
所属機関名
医学研究科
著者名
Shima, Yuko
著者名
Nakanishi, Koichi
著者名
Yoshikawa, Norishige
著者ID
A0877
研究者ID
1000000240854
著者名
Iijima, Kazumoto
飯島, 一誠
イイジマ, カヅモト
所属機関名
医学研究科
著者ID
A1366
研究者ID
1000070362796
KUID
https://kuid-rm-web.ofc.kobe-u.ac.jp/search/detail?systemId=cfe7f9e40ab7db60520e17560c007669
著者名
Nozu, Kandai
野津, 寛大
ノヅ, カンダイ
所属機関名
医学研究科
収録物名
Clinical and Experimental Nephrology
巻(号)
25(7)
ページ
779-787
出版者
Springer
刊行日
2021-07
公開日
2022-03-21
注記
Published online: 20 March 2021
抄録
Background Pathological findings in Alport syndrome frequently show mesangial proliferation and sometimes incidental IgA deposition, in addition to unique glomerular basement membrane (GBM) changes including thin basement membrane and/or lamellation. However, similar GBM abnormalities are also often observed in IgA nephropathy. Both diseases are also known to show hematuria, proteinuria, and sometimes macrohematuria when associated with viral infection. Therefore, it can be difficult to make a differential diagnosis, even based on clinical and pathological findings. Some recent articles demonstrated that galactose-deficient IgA1 (Gd-IgA1)-specific monoclonal antibody (KM55) could potentially enable incidental IgA deposition to be distinguished from IgA nephropathy. Methods We performed comprehensive gene screening and glomerular Gd-IgA1 and type IV collagen α5 chain immunostaining for five cases with both IgA deposition and GBM changes to confirm that Gd-IgA1 can help to distinguish these two diseases. Results Four of the cases were genetically diagnosed with Alport syndrome (Cases 1–4) and one was IgA nephropathy with massive GBM changes, which had a negative gene test result (Case 5). In Cases 1–4, glomerular Gd-IgA1 deposition was not detected, although there was positivity for IgA in the mesangial area. In Case 5, glomerular Gd-IgA1 deposition was observed. Conclusion Gd-IgA1 expression analysis could clearly differentiate these two disorders. This approach can be applied to identify these two diseases showing identical clinical and pathological findings.
キーワード
IgA nephropathy
Alport syndrome
Galactose-deficient IgA1
Glomerular basement membrane
カテゴリ
医学研究科
医学部附属病院
学術雑誌論文
権利
© Japanese Society of Nephrology 2021. This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature's AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s10157-021-02054-3